It looks like the monster from Critters, but not quite.

Archbio's got it

http://img441.imageshack.us/img441/8464/ub15n.jpg

Edit: Since it's a difficult mystery picture and the first 24 hours have passed, here's a hint:

The picture portrays a film within a film. Appearances may be deceiving.

Edit 2: It was a fictional porn movie (now with plot) within the real movie Boogie Nights. It had Burt Reynolds in it! Next pick is up for grabs. Phillistines.

What do you know, that was John C. Reilly after all. Well since it's up for grabs I'll take it. Hopefully this one will be easier:

The young man looks SO thrilled to have that father-figure in his life doesn't he?

1993's The Three Musketeers

Pictured is Sweet Transvestite
It also starred Rick "Wild Thing" Vaughn, Jack Bauer, Robin, and the guy who played the White House Counsel on the West Wing. Oh and Fiona from Burn Notice

Tim Curry playing The Devil playing The Cardinal of Richelieu.

Death by Stabbing for the win! Way to know how Disney can butcher even the best of classic literature while still pulling a surprising cast together. But it's ok, Tim Curry makes everything better, even communism. What'll we have up next DbS?

This is one of my favorite pictures.
Just look at that face.