I just liked how Kal'Reegar was like, "Yeah, sure, I'm a member of a race of what are essentially gypsy super-nerds, but even though I was just shot in the leg (which would normally cause a near-fatal allergic reaction) I'm still practically insisting on charging in with a rocket launcher!"
I just started what is technically my 4th playthrough today (concurrently with 2 others though). I'm on Casual difficulty because I want to see what it's like to import an ME2 character, and I don't like the guy I played as last time. For now I'm trying a Renegade playthrough for the first time... so fittingly, I'm playing a Soldier named
Havoc. He wears GDI-gold and blue, doesn't take no guff from no one, and uses a Hand Cannon exclusively. This is totally okay because Adrenaline Rush and Casual Difficulty combine to make headshots 1-or-2-shot kills. "And THAT was left-handed!"
In my other playthrough as an Adept on Insane, it took me about 12 hours to get to the point where I am. In my playthrough as Havoc, I've reached the same point in 2 hours. It's pretty awesome never dying from bullets.