Well, LSD is my favorite drug* and that's largely impossible to grow naturally.
As for spice, I've heard from a guy who knows a lot of drug users, and all sources say it's "Just like pot, except legal". "Russian roulette" should imply that one in six who try it are killed, so I'm thinking that article is full of scare-mongering.
*Not that I do drugs, it's just fascinating to read about.
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