[A Zarkin' Frood]

As someone used to the QWERTZ keyboard layout I say never map y or z to anything. Always bugs me. Oddly, though, it works for Robot Unicorn Attack.
There's also AZERTY and others, by the way, but I don't care about sad fuckers with AZERTY.

So, as for controls, what NonCon said pretty much. A mouse keyboard combo comes pretty natural for that kind of game.