While I am nerd, I am not on the whole 4e train, mainly a 3.5 junkie. I'll look at the system and give my ideas.
Though the big thing you have to realize first and foremost is that as a game, possibility has to be shrunken down, since complex interactions with the world are just writing in a tabletop, but hours of headaches for developers in a video game. There will be heavy trimming and modification to adapt the game to a mode where the computer is the DM.
But if you're still thinking of going with it then the big thing you want is to have a great foundation to build on, as the mod-friendlier it is, the more varied of adventures and settings that can be implemented officially, too. (Also mod campaigns are basically free level design labor so mod support is a must.) You basically want a good framework so that graphic and mechanical assets can be easily moved and modified without the base game shitting itself.
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